| 2. Jornada | 25.09.2021 | CF Monterrey [] | - | Mazatlán FC [] | 4:1 |  |
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| 3. Jornada | 02.10.2021 | Atlas Guadalajara [] | - | CF Monterrey [] | 2:1 | |
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| 4. Jornada | 09.10.2021 | CF Monterrey [] | - | Atlético San Luis [] | 4:0 | |
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| 5. Jornada | 16.10.2021 | Santos Laguna [] | - | CF Monterrey [] | 4:1 | |
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| 6. Jornada | 23.10.2021 | UANL Tigres [] | - | CF Monterrey [] | 2:1 | |
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| 7. Jornada | 30.10.2021 | CF Monterrey [] | - | Deportivo Guadalajara [] | 1:3 | |
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| 9. Jornada | 13.11.2021 | CF Monterrey [] | - | Club León [] | 2:2 | |
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| 10. Jornada | 20.11.2021 | Club Necaxa [] | - | CF Monterrey [] | 1:1 |  |
México