| 2. Jornada | 10.06.2021 | Rocha | - | Central Español | 3:2 |  |
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| 3. Jornada | 17.06.2021 | Central Español | - | CA Cerro | 3:2 | ||||
| 4. Jornada | 26.06.2021 | Defensor Sporting | - | Central Español | 4:0 | ||||
| 7. Jornada | 15.07.2021 | Racing | - | Central Español | 1:0 | ||||
| 8. Jornada | 24.07.2021 | Central Español | - | Villa Teresa | 2:1 | ||||
| 15. Jornada | 05.10.2021 | Central Español | - | Defensor Sporting | 1:0 | ||||
| 16. Jornada | 12.10.2021 | Central Español | - | Albion | 3:4 | ||||
| 22. Jornada | 25.11.2021 | Central Español | - | Rampla Juniors | 3:0 |
Uruguay