| 2. Jornada | 10.08.2021 | UNAN Managua | - | H&H Export Sébaco | 0:2 | ||||
| 3. Jornada | 15.08.2021 | H&H Export Sébaco | - | Club Deportivo Ocotal | 0:1 | ||||
| 5. Jornada | 29.08.2021 | Juventus Managua | - | H&H Export Sébaco | 1:0 | ||||
| 6. Jornada | 03.09.2021 | ART Municipal Jalapa | - | H&H Export Sébaco | 0:2 | ||||
| 7. Jornada | 12.09.2021 | H&H Export Sébaco | - | CD Walter Ferretti | 4:8 |
Nicaragua