| 1. Jornada | 01.08.2021 | Xelaju MC | - | Cobán Imperial | 3:0 |  |
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| 2. Jornada | 07.08.2021 | Cobán Imperial | - | Sololá FC | 0:0 | ||||
| 4. Jornada | 14.08.2021 | Cobán Imperial | - | Achuapa | 2:0 | ||||
| 3. Jornada | 18.08.2021 | Nueva Concepción | - | Cobán Imperial | 2:1 | ||||
| 5. Jornada | 22.08.2021 | Comunicaciones | - | Cobán Imperial | 2:2 | ||||
| 6. Jornada | 25.08.2021 | Deportivo Malacateco | - | Cobán Imperial | 1:0 | ||||
| 10. Jornada | 18.09.2021 | CSD Municipal | - | Cobán Imperial | 2:1 | ||||
| 11. Jornada | 25.09.2021 | Cobán Imperial | - | Iztapa | 2:1 | ||||
| 12. Jornada | 02.10.2021 | Cobán Imperial | - | Xelaju MC | 1:1 | |
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| 13. Jornada | 10.10.2021 | Sololá FC | - | Cobán Imperial | 1:2 | ||||
| 8. Jornada | 13.10.2021 | Deportivo Guastatoya | - | Cobán Imperial | 0:1 | ||||
| 15. Jornada | 23.10.2021 | Achuapa | - | Cobán Imperial | 1:0 | ||||
| 17. Jornada | 31.10.2021 | Cobán Imperial | - | Deportivo Malacateco | 1:1 | ||||
| 21. Jornada | 28.11.2021 | Cobán Imperial | - | CSD Municipal | 0:1 |
Guatemala