| 3. Jornada | 07.08.2021 | Cruz Azul [Sub 16] | - | Club Tijuana [Sub 16] | 3:0 | ||||
| 4. Jornada | 14.08.2021 | Gallos Blancos [Sub 16] | - | Cruz Azul [Sub 16] | 3:0 | ||||
| 12. Jornada | 09.10.2021 | FC Juárez [Sub 16] | - | Cruz Azul [Sub 16] | 0:2 | ||||
| 8. Jornada | 20.10.2021 | Puebla FC [Sub 16] | - | Cruz Azul [Sub 16] | 1:2 | ||||
| 15. Jornada | 30.10.2021 | Pumas UNAM [Sub 16] | - | Cruz Azul [Sub 16] | 2:0 | ||||
| 18. Jornada | 20.11.2021 | Club Tijuana [Sub 16] | - | Cruz Azul [Sub 16] | 0:0 |
México