| 1. Jornada | 21.01.2022 | Marathón | - | Platense | 1:0 |  |
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| 4. Jornada | 11.02.2022 | Marathón | - | Real España | 2:0 | ||||
| 6. Jornada | 19.02.2022 | Marathón | - | Victoria | 2:3 | ||||
| 7. Jornada | 27.02.2022 | Real Sociedad | - | Marathón | 1:0 | ||||
| 9. Jornada | 07.03.2022 | Marathón | - | Lobos UPNFM | 4:1 | ||||
| 10. Jornada | 13.03.2022 | Marathón | - | Vida | 1:1 | ||||
| 11. Jornada | 21.03.2022 | Olimpia | - | Marathón | 3:0 | ||||
| 14. Jornada | 10.04.2022 | Victoria | - | Marathón | 0:1 | ||||
| 15. Jornada | 13.04.2022 | Marathón | - | Motagua | 0:3 | ||||
| 17. Jornada | 25.04.2022 | Marathón | - | Real Sociedad | 6:0 | ||||
| 12. Jornada | 28.04.2022 | Real España | - | Marathón | 3:1 | ||||
| 18. Jornada | 01.05.2022 | Lobos UPNFM | - | Marathón | 1:2 |
Honduras