| 1. Jornada | 12.12.2020 | Al Mokawloon | - | Zamalek | 0:2 | ||||
| 2. Jornada | 17.12.2020 | Pyramids FC | - | Zamalek | 1:1 | ||||
| 3. Jornada | 28.12.2020 | Smouha Sporting Club | - | Zamalek | 0:2 | ||||
| 5. Jornada | 02.01.2021 | ENPPI | - | Zamalek | 1:2 | ||||
| 6. Jornada | 09.01.2021 | Zamalek | - | Tala'ea El Gaish SC | 3:0 | ||||
| 7. Jornada | 12.01.2021 | Al Masry Club | - | Zamalek | 0:1 | ||||
| 8. Jornada | 19.01.2021 | Zamalek | - | El Gouna | 1:0 | ||||
| 9. Jornada | 23.01.2021 | Aswan SC | - | Zamalek | 0:0 | ||||
| 10. Jornada | 28.01.2021 | Zamalek | - | Misr lel-Maqasah SC | 4:1 | ||||
| 11. Jornada | 02.02.2021 | Ghazl Al Mehalla | - | Zamalek | 2:1 | ||||
| 12. Jornada | 07.02.2021 | Zamalek | - | Ittihad El Iskandary | 2:0 | ||||
| 13. Jornada | 17.02.2021 | Zamalek | - | Ismaily | 2:1 | ||||
| 16. Jornada | 22.04.2021 | El Entag El Harby | - | Zamalek | 0:2 | ||||
| 17. Jornada | 26.04.2021 | Zamalek | - | National Bank SC | 4:1 | ||||
| 31. Jornada | 17.08.2021 | Zamalek | - | Wadi Degla SC | 1:0 | ||||
| 32. Jornada | 20.08.2021 | Ceramica Cleopatra | - | Zamalek | 1:2 | ||||
| 33. Jornada | 24.08.2021 | Zamalek | - | El Entag El Harby | 2:0 | ||||
| 34. Jornada | 27.08.2021 | National Bank SC | - | Zamalek | 1:1 |
Egipto