| 1. Jornada | 07.08.2010 | Newell's Old Boys | - | Estudiantes | 0:1 |  |
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| 2. Jornada | 14.08.2010 | CA Lanús | - | Newell's Old Boys | 1:1 | ||||
| 3. Jornada | 21.08.2010 | Newell's Old Boys | - | Tigre | 2:0 | |
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| 4. Jornada | 28.08.2010 | Huracán | - | Newell's Old Boys | 1:1 | ||||
| 5. Jornada | 05.09.2010 | Newell's Old Boys | - | Independiente | 1:1 | ||||
| 6. Jornada | 12.09.2010 | Argentinos Juniors | - | Newell's Old Boys | 1:2 |  |
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| 7. Jornada | 19.09.2010 | Newell's Old Boys | - | River Plate | 1:0 | ||||
| 8. Jornada | 26.09.2010 | Arsenal de Sarandí | - | Newell's Old Boys | 0:0 | ||||
| 9. Jornada | 02.10.2010 | Newell's Old Boys | - | Vélez Sarsfield | 2:0 | |
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| 13. Jornada | 06.11.2010 | Godoy Cruz | - | Newell's Old Boys | 0:0 | ||||
| 14. Jornada | 15.11.2010 | Newell's Old Boys | - | Racing Club | 0:2 | |
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| 15. Jornada | 20.11.2010 | All Boys | - | Newell's Old Boys | 2:0 | ||||
| 16. Jornada | 28.11.2010 | Newell's Old Boys | - | Boca Juniors | 1:0 | ||||
| 17. Jornada | 05.12.2010 | San Lorenzo | - | Newell's Old Boys | 0:0 | ||||
| 18. Jornada | 09.12.2010 | Newell's Old Boys | - | Olimpo de Bahía Blanca | 0:1 | |
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