| 6. Jornada | 03.04.2022 | Orense SC | - | Mushuc Runa | 0:0 | ||||
| 7. Jornada | 11.04.2022 | Barcelona | - | Orense SC | 2:0 | ||||
| 9. Jornada | 20.04.2022 | Orense SC | - | LDU Quito | 3:0 | ||||
| 10. Jornada | 23.04.2022 | Gualaceo SC | - | Orense SC | 2:1 | ||||
| 11. Jornada | 01.05.2022 | Orense SC | - | Universidad Catolica | 1:0 | ||||
| 12. Jornada | 07.05.2022 | Delfín SC | - | Orense SC | 2:1 | ||||
| 13. Jornada | 15.05.2022 | Orense SC | - | Emelec | 2:0 | ||||
| 14. Jornada | 24.05.2022 | Deportivo Cuenca | - | Orense SC | 1:1 |  |
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| 15. Jornada | 28.05.2022 | Orense SC | - | Guayaquil City | 0:1 | |
Ecuador