| 7. Jornada | 14.02.2025 | Mazatlán FC [Sub 23] | - | Santos Laguna [Sub 23] | 1:5 | ||||
| 8. Jornada | 23.02.2025 | Santos Laguna [Sub 23] | - | Atlas Guadalajara [Sub 23] | 2:0 | ||||
| 11. Jornada | 09.03.2025 | Santos Laguna [Sub 23] | - | Club León [Sub 23] | 2:0 | ||||
| 12. Jornada | 15.03.2025 | UANL Tigres [Sub 23] | - | Santos Laguna [Sub 23] | 3:1 |  |
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| 13. Jornada | 30.03.2025 | Santos Laguna [Sub 23] | - | Atlético San Luis [Sub 23] | 1:0 | ||||
| 14. Jornada | 06.04.2025 | Deportivo Toluca [Sub 23] | - | Santos Laguna [Sub 23] | 1:0 | ||||
| 15. Jornada | 13.04.2025 | Santos Laguna [Sub 23] | - | Gallos Blancos [Sub 23] | 2:0 |  |
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| 16. Jornada | 16.04.2025 | Pumas UNAM [Sub 23] | - | Santos Laguna [Sub 23] | 2:0 | |
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| 17. Jornada | 20.04.2025 | Santos Laguna [Sub 23] | - | Club Tijuana [Sub 23] | 1:0 |
México