| 1. Jornada | 13.01.2022 | Municipal Pérez Zeledón | - | Municipal Grecia | 1:1 | ||||
| 2. Jornada | 16.01.2022 | CS Cartaginés | - | Municipal Pérez Zeledón | 2:1 | ||||
| 3. Jornada | 22.01.2022 | AD San Carlos | - | Municipal Pérez Zeledón | 1:1 | ||||
| 4. Jornada | 04.02.2022 | Municipal Pérez Zeledón | - | LD Alajuelense | 2:1 |  |
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| 5. Jornada | 09.02.2022 | AD Guanacasteca | - | Municipal Pérez Zeledón | 0:0 | ||||
| 6. Jornada | 13.02.2022 | Santos de Guápiles | - | Municipal Pérez Zeledón | 0:1 | ||||
| 7. Jornada | 20.02.2022 | Municipal Pérez Zeledón | - | Deportivo Saprissa | 0:0 | ||||
| 8. Jornada | 26.02.2022 | Sporting FC | - | Municipal Pérez Zeledón | 1:1 | ||||
| 9. Jornada | 03.03.2022 | Municipal Pérez Zeledón | - | Guadalupe | 0:1 | ||||
| 10. Jornada | 08.03.2022 | Municipal Pérez Zeledón | - | Jicaral | 2:1 |  |
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| 20. Jornada | 08.05.2022 | Guadalupe | - | Municipal Pérez Zeledón | 2:2 | ||||
| 21. Jornada | 11.05.2022 | Jicaral | - | Municipal Pérez Zeledón | 2:1 | ||||
| 22. Jornada | 15.05.2022 | Municipal Pérez Zeledón | - | CS Herediano | 2:3 |
Costa Rica