| 1. Jornada | 09.07.2017 | FC Milsami | - | Speranţa Nisporeni | 0:1 |  |
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| 2. Jornada | 15.07.2017 | Spicul Chișcăreni | - | Speranţa Nisporeni | 1:1 | ||||
| 3. Jornada | 24.07.2017 | Speranţa Nisporeni | - | FC Zaria | 2:4 | ||||
| 4. Jornada | 30.07.2017 | Dacia Chişinău | - | Speranţa Nisporeni | 2:1 | |
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| 5. Jornada | 04.08.2017 | Speranţa Nisporeni | - | FC Zimbru | 1:0 | ||||
| 6. Jornada | 12.08.2017 | CS Petrocub | - | Speranţa Nisporeni | 1:1 |  |
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| 8. Jornada | 25.08.2017 | FC Sfîntul Gheorghe | - | Speranţa Nisporeni | 2:1 | ||||
| 9. Jornada | 10.09.2017 | Speranţa Nisporeni | - | FC Sheriff | 1:2 | |
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| 10. Jornada | 16.09.2017 | Speranţa Nisporeni | - | FC Milsami | 1:3 | |
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| 12. Jornada | 30.09.2017 | FC Zaria | - | Speranţa Nisporeni | 3:0 | ||||
| 13. Jornada | 14.10.2017 | Speranţa Nisporeni | - | Dacia Chişinău | 0:0 | ||||
| 14. Jornada | 20.10.2017 | FC Zimbru | - | Speranţa Nisporeni | 2:1 | |
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| 15. Jornada | 29.10.2017 | Speranţa Nisporeni | - | CS Petrocub | 0:0 | ||||
| 16. Jornada | 04.11.2017 | Dinamo-Auto | - | Speranţa Nisporeni | 0:3 |  |
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| 17. Jornada | 18.11.2017 | Speranţa Nisporeni | - | FC Sfîntul Gheorghe | 0:0 | ||||
| 18. Jornada | 26.11.2017 | FC Sheriff | - | Speranţa Nisporeni | 0:1 | |
Rusia