| 1. Jornada | 18.08.2021 | Progrès Niedercorn | - | FC Differdange 03 | 3:0 | ||||
| 3. Jornada | 22.08.2021 | FC Differdange 03 | - | CS FOLA Esch | 1:1 | ||||
| 5. Jornada | 12.09.2021 | FC Differdange 03 | - | Swift Hesperange | 0:0 |  |
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| 7. Jornada | 22.09.2021 | FC Differdange 03 | - | RM Hamm Benfica | 3:0 | ||||
| 9. Jornada | 17.10.2021 | FC Differdange 03 | - | F91 Dudelange | 3:2 | ||||
| 11. Jornada | 07.11.2021 | FC Differdange 03 | - | US Hostert | 1:4 | |
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| 13. Jornada | 28.11.2021 | FC Differdange 03 | - | Union Titus Pétange | 4:0 | ||||
| 14. Jornada | 05.12.2021 | US Mondorf | - | FC Differdange 03 | 3:3 | |
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| 16. Jornada | 06.02.2022 | FC Differdange 03 | - | Victoria Rosport | 4:0 | ||||
| 26. Jornada | 24.04.2022 | FC Differdange 03 | - | RFCU Luxemburg | 4:0 | ||||
| 28. Jornada | 08.05.2022 | FC Differdange 03 | - | US Mondorf | 1:0 | ||||
| 29. Jornada | 15.05.2022 | Etzella Ettelbruck | - | FC Differdange 03 | 0:2 | ||||
| 30. Jornada | 22.05.2022 | FC Differdange 03 | - | Progrès Niedercorn | 2:0 |
Luxemburgo
Italia