| 6. Jornada | 18.10.2021 | APOEL Nikosia | - | Ethnikos Achna | 2:1 |  |
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| 7. Jornada | 24.10.2021 | Aris Limassol | - | APOEL Nikosia | 0:1 | ||||
| 9. Jornada | 06.11.2021 | APOEL Nikosia | - | AEL Limassol | 3:0 | ||||
| 10. Jornada | 22.11.2021 | AEK Larnaca | - | APOEL Nikosia | 0:0 | |
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| 12. Jornada | 05.12.2021 | APOEL Nikosia | - | Paphos FC | 1:1 | ||||
| 13. Jornada | 12.12.2021 | Olympiacos Nikosia | - | APOEL Nikosia | 1:1 | ||||
| 11. Jornada | 26.12.2021 | APOEL Nikosia | - | Omonia Nikosia | 4:2 |  |
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| 17. Jornada | 15.01.2022 | Ethnikos Achna | - | APOEL Nikosia | 0:3 | |
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| 18. Jornada | 23.01.2022 | APOEL Nikosia | - | Aris Limassol | 1:1 |
Chipre