| 8. Jornada | 12.09.2021 | NK Istra 1961 | - | Hajduk Split | 1:3 | ||||
| 10. Jornada | 27.09.2021 | Hrvatski Dragovoljac | - | NK Istra 1961 | 0:1 | ||||
| 11. Jornada | 02.10.2021 | NK Istra 1961 | - | HNK Rijeka | 3:6 | ||||
| 13. Jornada | 24.10.2021 | Dinamo Zagreb | - | NK Istra 1961 | 1:1 | ||||
| 15. Jornada | 06.11.2021 | NK Osijek | - | NK Istra 1961 | 3:0 | ||||
| 16. Jornada | 20.11.2021 | NK Istra 1961 | - | HNK Šibenik | 3:4 |  |
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| 17. Jornada | 26.11.2021 | Hajduk Split | - | NK Istra 1961 | 4:0 | ||||
| 33. Jornada | 01.05.2022 | NK Osijek | - | NK Istra 1961 | 2:2 | ||||
| 35. Jornada | 14.05.2022 | Hajduk Split | - | NK Istra 1961 | 3:1 | ||||
| 36. Jornada | 20.05.2022 | NK Istra 1961 | - | Slaven Belupo | 3:1 |
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