| 1. Jornada | 17.07.2021 | Universidad San Martín | - | Mannucci | 0:2 |  |
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| 2. Jornada | 23.07.2021 | Mannucci | - | Deportivo Municipal | 1:2 |  |
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| 3. Jornada | 31.07.2021 | Universitario de Deportes | - | Mannucci | 1:3 | ||||
| 4. Jornada | 03.08.2021 | Mannucci | - | Sport Huancayo | 1:1 | ||||
| 5. Jornada | 07.08.2021 | César Vallejo | - | Mannucci | 0:1 | |
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| 6. Jornada | 13.08.2021 | Mannucci | - | Deportivo Binacional | 3:1 | ||||
| 7. Jornada | 17.08.2021 | Cusco FC | - | Mannucci | 2:3 | |
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| 8. Jornada | 21.08.2021 | Mannucci | - | FBC Melgar | 1:2 | ||||
| 9. Jornada | 28.08.2021 | Alianza Atlético | - | Mannucci | 2:0 | ||||
| 10. Jornada | 12.09.2021 | Mannucci | - | Universidad Técnica | 1:3 | ||||
| 11. Jornada | 18.09.2021 | Mannucci | - | Alianza Universidad | 1:1 | |
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| 13. Jornada | 25.09.2021 | Mannucci | - | Cienciano | 1:3 | ||||
| 14. Jornada | 01.10.2021 | Ayacucho FC | - | Mannucci | 3:2 | |
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| 15. Jornada | 16.10.2021 | Mannucci | - | Alianza Lima | 0:1 | |
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| 16. Jornada | 22.10.2021 | Sport Boys | - | Mannucci | 3:3 | ||||
| 17. Jornada | 30.10.2021 | Mannucci | - | Academia Cantolao | 1:0 | |
Uruguay