| 22. Jornada | 30.07.2021 | Drogheda United | - | Waterford FC | 1:2 | ||||
| 23. Jornada | 07.08.2021 | Waterford FC | - | Bohemian FC | 1:0 | ||||
| 24. Jornada | 13.08.2021 | St Patrick's Athletic | - | Waterford FC | 2:1 |  |
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| 26. Jornada | 03.09.2021 | Waterford FC | - | Dundalk FC | 1:1 | ||||
| 27. Jornada | 10.09.2021 | Shamrock Rovers | - | Waterford FC | 2:0 | |
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| 28. Jornada | 24.09.2021 | Waterford FC | - | Drogheda United | 1:0 | ||||
| 31. Jornada | 15.10.2021 | Waterford FC | - | Finn Harps | 4:1 | |
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| 32. Jornada | 25.10.2021 | Bohemian FC | - | Waterford FC | 1:2 | ||||
| 33. Jornada | 29.10.2021 | Dundalk FC | - | Waterford FC | 1:0 | ||||
| 30. Jornada | 02.11.2021 | Waterford FC | - | Derry City | 2:2 |  |
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| 34. Jornada | 05.11.2021 | Waterford FC | - | Shamrock Rovers | 1:3 | ||||
| 35. Jornada | 13.11.2021 | Longford Town | - | Waterford FC | 1:1 |  |
Inglaterra