| 1. Jornada | 24.07.2021 | KV Oostende | - | Sporting Charleroi | 0:3 | ||||
| 2. Jornada | 31.07.2021 | Sporting Charleroi | - | Sint-Truidense VV | 0:0 | ||||
| 3. Jornada | 08.08.2021 | Oud-Heverlee Leuven | - | Sporting Charleroi | 1:1 | ||||
| 5. Jornada | 22.08.2021 | SV Zulte Waregem | - | Sporting Charleroi | 2:2 | ||||
| 11. Jornada | 17.10.2021 | Sporting Charleroi | - | KRC Genk | 2:0 | ||||
| 12. Jornada | 22.10.2021 | RFC Seraing | - | Sporting Charleroi | 1:3 | ||||
| 13. Jornada | 30.10.2021 | Sporting Charleroi | - | KAS Eupen | 3:0 | ||||
| 15. Jornada | 20.11.2021 | Cercle Brugge | - | Sporting Charleroi | 1:2 | ||||
| 17. Jornada | 05.12.2021 | Standard Liège | - | Sporting Charleroi | 0:3 | ||||
| 18. Jornada | 10.12.2021 | Sporting Charleroi | - | KV Oostende | 1:0 | ||||
| 20. Jornada | 19.12.2021 | KAS Eupen | - | Sporting Charleroi | 0:4 | ||||
| 21. Jornada | 27.12.2021 | Sporting Charleroi | - | Oud-Heverlee Leuven | 0:3 |
Bélgica