| 13. Jornada | 24.09.2021 | Newell's Old Boys II | - | Huracán II | 2:0 | ||||
| 15. Jornada | 08.10.2021 | Newell's Old Boys II | - | Vélez Sarsfield II | 0:0 | ||||
| 18. Jornada | 22.10.2021 | Sarmiento de Junín II | - | Newell's Old Boys II | 1:2 |  |
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| 21. Jornada | 17.11.2021 | Arsenal de Sarandí II | - | Newell's Old Boys II | 0:3 | ||||
| 23. Jornada | 30.11.2021 | Boca Juniors II | - | Newell's Old Boys II | 1:0 | ||||
| 24. Jornada | 06.12.2021 | Newell's Old Boys II | - | Banfield II | 2:0 | ||||
| 25. Jornada | 10.12.2021 | San Lorenzo II | - | Newell's Old Boys II | 2:1 |
Argentina