| 1. Jornada | 31.08.2016 | Boston River | - | Defensor Sporting | 1:1 |  |
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| 2. Jornada | 04.09.2016 | Defensor Sporting | - | Juventud de Las Piedras | 0:1 | ||||
| 3. Jornada | 11.09.2016 | Defensor Sporting | - | Sud América | 2:0 | ||||
| 4. Jornada | 18.09.2016 | River Plate | - | Defensor Sporting | 0:5 | ||||
| 5. Jornada | 24.09.2016 | Defensor Sporting | - | CA Cerro | 0:1 | |
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| 6. Jornada | 02.10.2016 | Defensor Sporting | - | Montevideo Wanderers | 1:1 |  |
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| 7. Jornada | 09.10.2016 | Fénix | - | Defensor Sporting | 3:1 | ||||
| 8. Jornada | 16.10.2016 | Defensor Sporting | - | Liverpool | 1:3 | ||||
| 9. Jornada | 23.10.2016 | Plaza Colonia | - | Defensor Sporting | 0:1 | ||||
| 10. Jornada | 29.10.2016 | Rampla Juniors | - | Defensor Sporting | 0:1 | |
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| 12. Jornada | 20.11.2016 | Defensor Sporting | - | Nacional | 3:2 | |
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| 13. Jornada | 26.11.2016 | Defensor Sporting | - | Danubio | 0:0 | ||||
| 14. Jornada | 04.12.2016 | Defensor Sporting | - | Racing | 2:1 | ||||
| 15. Jornada | 10.12.2016 | Peñarol | - | Defensor Sporting | 0:2 |
Uruguay