| 1. Jornada | 25.07.2021 | KV Mechelen | - | Royal Antwerp FC | 3:2 | ||||
| 2. Jornada | 31.07.2021 | RFC Seraing | - | KV Mechelen | 1:0 |  |
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| 3. Jornada | 07.08.2021 | KV Mechelen | - | KAS Eupen | 1:3 | ||||
| 4. Jornada | 15.08.2021 | Gante | - | KV Mechelen | 2:0 | ||||
| 8. Jornada | 18.09.2021 | KV Mechelen | - | Oud-Heverlee Leuven | 2:0 | ||||
| 15. Jornada | 19.11.2021 | KV Mechelen | - | Club Brugge KV | 2:1 | ||||
| 16. Jornada | 27.11.2021 | Cercle Brugge | - | KV Mechelen | 3:1 | ||||
| 17. Jornada | 05.12.2021 | KV Mechelen | - | KRC Genk | 1:1 | ||||
| 27. Jornada | 12.02.2022 | KV Mechelen | - | KV Oostende | 3:0 | ||||
| 24. Jornada | 16.02.2022 | KRC Genk | - | KV Mechelen | 4:1 | ||||
| 28. Jornada | 20.02.2022 | Royal Antwerp FC | - | KV Mechelen | 1:2 | ||||
| 30. Jornada | 04.03.2022 | Sint-Truidense VV | - | KV Mechelen | 1:1 | ||||
| 32. Jornada | 19.03.2022 | KAS Eupen | - | KV Mechelen | 1:1 | ||||
| 33. Jornada | 02.04.2022 | KV Mechelen | - | KV Kortrijk | 3:2 | ||||
| 34. Jornada | 10.04.2022 | Club Brugge KV | - | KV Mechelen | 2:0 |
Suecia