| 1. Jornada | 19.02.2022 | LDU Quito | - | Gualaceo SC | 1:0 |  |
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| 2. Jornada | 27.02.2022 | Gualaceo SC | - | Cumbayá | 0:1 | ||||
| 3. Jornada | 08.03.2022 | Deportivo Cuenca | - | Gualaceo SC | 2:1 | |
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| 4. Jornada | 14.03.2022 | Gualaceo SC | - | Emelec | 2:1 |  |
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| 5. Jornada | 20.03.2022 | 9 de Octubre | - | Gualaceo SC | 1:1 | ||||
| 6. Jornada | 02.04.2022 | Gualaceo SC | - | Independiente del Valle | 1:3 | ||||
| 7. Jornada | 09.04.2022 | Técnico Universitario | - | Gualaceo SC | 1:1 | |
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| 8. Jornada | 16.04.2022 | Gualaceo SC | - | Mushuc Runa | 3:2 | ||||
| 10. Jornada | 23.04.2022 | Gualaceo SC | - | Orense SC | 2:1 | |
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| 12. Jornada | 08.05.2022 | Universidad Catolica | - | Gualaceo SC | 3:1 | ||||
| 13. Jornada | 17.05.2022 | Gualaceo SC | - | Guayaquil City | 2:1 | ||||
| 14. Jornada | 21.05.2022 | Delfín SC | - | Gualaceo SC | 1:0 | ||||
| 15. Jornada | 28.05.2022 | Gualaceo SC | - | Aucas | 1:4 |  |
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