| 5. Jornada | 30.08.2021 | Real Estelí FC | - | ART Municipal Jalapa | 2:0 | ||||
| 13. Jornada | 21.10.2021 | CD Walter Ferretti | - | ART Municipal Jalapa | 5:0 | ||||
| 14. Jornada | 24.10.2021 | ART Municipal Jalapa | - | Real Estelí FC | 2:1 | ||||
| 15. Jornada | 01.11.2021 | ART Municipal Jalapa | - | Real Madriz | 0:1 | ||||
| 16. Jornada | 04.11.2021 | H&H Export Sébaco | - | ART Municipal Jalapa | 3:0 | ||||
| 18. Jornada | 22.11.2021 | Diriangén FC | - | ART Municipal Jalapa | 5:0 |
Nicaragua