| 1. Jornada | 12.03.2021 | Real Tomayapo | - | Always Ready | 1:0 |  |
|||
| 2. Jornada | 14.03.2021 | Always Ready | - | Club San José | 5:0 | ||||
| 3. Jornada | 03.04.2021 | Real Santa Cruz | - | Always Ready | 2:3 | ||||
| 4. Jornada | 10.04.2021 | Always Ready | - | Nacional Potosí | 1:1 | |
|||
| 18. Jornada | 14.09.2021 | Always Ready | - | Real Santa Cruz | 4:0 | ||||
| 19. Jornada | 19.09.2021 | Nacional Potosí | - | Always Ready | 0:2 | ||||
| 20. Jornada | 23.09.2021 | Always Ready | - | Oriente Petrolero | 2:0 | ||||
| 21. Jornada | 27.09.2021 | The Strongest | - | Always Ready | 1:1 | ||||
| 23. Jornada | 24.10.2021 | Atlético Palmaflor | - | Always Ready | 0:1 | ||||
| 24. Jornada | 27.10.2021 | Always Ready | - | Independiente Petrolero | 2:2 | |
|||
| 25. Jornada | 31.10.2021 | Always Ready | - | Royal Pari | 2:1 | |
Panamá