| 5. Jornada | 22.11.2021 | Zamalek | - | National Bank SC | 1:1 | ||||
| 6. Jornada | 25.11.2021 | Ceramica Cleopatra | - | Zamalek | 0:1 | ||||
| 7. Jornada | 21.12.2021 | Al Mokawloon | - | Zamalek | 1:2 | ||||
| 8. Jornada | 25.12.2021 | Zamalek | - | Ghazl Al Mehalla | 4:0 | ||||
| 10. Jornada | 02.03.2022 | Zamalek | - | Future FC | 3:2 | ||||
| 12. Jornada | 07.03.2022 | Zamalek | - | El Gouna | 2:1 | ||||
| 11. Jornada | 06.04.2022 | Pyramids FC | - | Zamalek | 2:3 | ||||
| 13. Jornada | 09.04.2022 | Misr lel-Maqasah SC | - | Zamalek | 0:1 | ||||
| 14. Jornada | 12.04.2022 | Zamalek | - | Pharco FC | 0:0 | ||||
| 17. Jornada | 01.05.2022 | El Sharkia Lel Dokhan | - | Zamalek | 1:2 | ||||
| 18. Jornada | 10.05.2022 | Zamalek | - | ENPPI | 0:2 | ||||
| 19. Jornada | 17.05.2022 | Zamalek | - | Tala'ea El Gaish SC | 0:1 | ||||
| 21. Jornada | 28.05.2022 | Zamalek | - | Ismaily | 2:1 | ||||
| 26. Jornada | 24.07.2022 | Zamalek | - | Smouha Sporting Club | 2:0 | ||||
| 28. Jornada | 01.08.2022 | Zamalek | - | Pyramids FC | 3:0 | ||||
| 29. Jornada | 05.08.2022 | El Gouna | - | Zamalek | 1:4 | ||||
| 32. Jornada | 23.08.2022 | Zamalek | - | Ittihad El Iskandary | 1:1 | ||||
| 33. Jornada | 26.08.2022 | Al Masry Club | - | Zamalek | 0:0 |
Egipto