| 1. Jornada | 05.02.2022 | Defensor Sporting | - | Liverpool | 0:3 |  |
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| 2. Jornada | 13.02.2022 | Liverpool | - | Albion | 4:0 | |
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| 3. Jornada | 22.02.2022 | Nacional | - | Liverpool | 0:0 | ||||
| 4. Jornada | 26.02.2022 | Liverpool | - | Danubio | 0:1 | ||||
| 5. Jornada | 05.03.2022 | Deportivo Maldonado | - | Liverpool | 1:0 | ||||
| 6. Jornada | 20.03.2022 | Liverpool | - | Rentistas | 1:0 | ||||
| 7. Jornada | 03.04.2022 | Cerrito | - | Liverpool | 0:1 | |
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| 8. Jornada | 09.04.2022 | Peñarol | - | Liverpool | 2:1 | ||||
| 9. Jornada | 16.04.2022 | Liverpool | - | Montevideo City Torque | 2:0 | ||||
| 10. Jornada | 23.04.2022 | Montevideo Wanderers | - | Liverpool | 0:0 | |
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| 11. Jornada | 07.05.2022 | Liverpool | - | Plaza Colonia | 1:0 | ||||
| 12. Jornada | 16.05.2022 | Boston River | - | Liverpool | 2:3 | ||||
| 13. Jornada | 22.05.2022 | Liverpool | - | River Plate | 2:1 | ||||
| 14. Jornada | 28.05.2022 | Cerro Largo | - | Liverpool | 1:2 | ||||
| 15. Jornada | 05.06.2022 | Liverpool | - | Fénix | 1:0 | |
Uruguay