| 1. Jornada | 24.01.2019 | Guaraní | - | Cerro Porteño | 0:1 | ||||
| 2. Jornada | 27.01.2019 | Libertad | - | Cerro Porteño | 1:0 | ||||
| 4. Jornada | 06.02.2019 | General Díaz | - | Cerro Porteño | 1:3 |  |
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| 5. Jornada | 11.02.2019 | Cerro Porteño | - | River Plate | 3:1 | ||||
| 7. Jornada | 23.02.2019 | Cerro Porteño | - | Club Nacional | 1:1 | |
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| 8. Jornada | 26.02.2019 | San Lorenzo | - | Cerro Porteño | 2:1 |  |
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| 9. Jornada | 03.03.2019 | Cerro Porteño | - | Sportivo Luqueño | 2:0 | |
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| 10. Jornada | 10.03.2019 | Deportivo Santaní | - | Cerro Porteño | 1:3 | |
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| 12. Jornada | 23.03.2019 | Cerro Porteño | - | Guaraní | 5:2 | |
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| 13. Jornada | 30.03.2019 | Cerro Porteño | - | Libertad | 1:2 | |
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| 16. Jornada | 14.04.2019 | River Plate | - | Cerro Porteño | 1:5 | |
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| 17. Jornada | 20.04.2019 | Cerro Porteño | - | Club Olimpia | 1:3 | |
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| 18. Jornada | 29.04.2019 | Club Nacional | - | Cerro Porteño | 0:3 | |
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| 19. Jornada | 01.05.2019 | Cerro Porteño | - | San Lorenzo | 1:1 | |
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| 21. Jornada | 12.05.2019 | Cerro Porteño | - | Deportivo Santaní | 3:2 | |
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| 20. Jornada | 16.05.2019 | Sportivo Luqueño | - | Cerro Porteño | 2:1 | |
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| 22. Jornada | 20.05.2019 | Sol de América | - | Cerro Porteño | 0:1 |
Uruguay