| 1. Jornada | 09.01.2021 | Puebla FC | - | Deportivo Guadalajara | 1:1 |  |
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| 2. Jornada | 17.01.2021 | Deportivo Guadalajara | - | Deportivo Toluca | 1:1 | ||||
| 3. Jornada | 22.01.2021 | Atlético San Luis | - | Deportivo Guadalajara | 3:1 | |
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| 4. Jornada | 31.01.2021 | Deportivo Guadalajara | - | FC Juárez | 1:2 | ||||
| 5. Jornada | 09.02.2021 | Club León | - | Deportivo Guadalajara | 1:3 | |
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| 6. Jornada | 14.02.2021 | Deportivo Guadalajara | - | Club Necaxa | 2:2 | ||||
| 7. Jornada | 23.02.2021 | CF Pachuca | - | Deportivo Guadalajara | 1:1 | ||||
| 8. Jornada | 01.03.2021 | Deportivo Guadalajara | - | Pumas UNAM | 2:1 | ||||
| 13. Jornada | 05.04.2021 | Deportivo Guadalajara | - | Santos Laguna | 1:1 |
México