| 5. Jornada | 28.08.2021 | GFK Tikvesh | - | FC Struga | 1:1 | ||||
| 10. Jornada | 16.10.2021 | FC Struga | - | FK Borec | 1:1 | ||||
| 12. Jornada | 30.10.2021 | FC Struga | - | FK AP Brera Strumica | 0:0 | ||||
| 13. Jornada | 06.11.2021 | FK Pelister | - | FC Struga | 0:1 |  |
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| 14. Jornada | 21.11.2021 | FC Struga | - | FK Rabotnički | 1:0 | ||||
| 16. Jornada | 05.12.2021 | FC Struga | - | GFK Tikvesh | 0:0 | ||||
| 17. Jornada | 08.12.2021 | FK Skopje | - | FC Struga | 1:0 | ||||
| 18. Jornada | 14.12.2021 | FC Struga | - | FK Renova | 1:0 | ||||
| 19. Jornada | 13.02.2022 | KF Shkëndija 79 | - | FC Struga | 3:1 | ||||
| 20. Jornada | 20.02.2022 | FC Struga | - | FK Bregalnica Štip | 1:1 | ||||
| 23. Jornada | 13.03.2022 | FK AP Brera Strumica | - | FC Struga | 1:0 |  |
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| 24. Jornada | 18.03.2022 | FC Struga | - | KF Shkupi | 1:3 | ||||
| 25. Jornada | 02.04.2022 | FK Rabotnički | - | FC Struga | 1:3 | ||||
| 26. Jornada | 06.04.2022 | GFK Tikvesh | - | FC Struga | 2:0 | |
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| 27. Jornada | 10.04.2022 | FC Struga | - | FK Skopje | 1:0 |
Macedonia del Norte