| 2. Jornada | 16.01.2022 | Club Tijuana [Sub 20] | - | Club León [Sub 20] | 1:2 | ||||
| 1. Jornada | 19.01.2022 | Club León [Sub 20] | - | Atlas Guadalajara [Sub 20] | 1:1 | ||||
| 5. Jornada | 13.02.2022 | Pumas UNAM [Sub 20] | - | Club León [Sub 20] | 2:1 | ||||
| 9. Jornada | 04.03.2022 | FC Juárez [Sub 20] | - | Club León [Sub 20] | 0:1 | ||||
| 13. Jornada | 09.04.2022 | Atlético San Luis [Sub 20] | - | Club León [Sub 20] | 1:1 | ||||
| 14. Jornada | 16.04.2022 | Club León [Sub 20] | - | Puebla FC [Sub 20] | 4:1 | ||||
| 15. Jornada | 20.04.2022 | CF América [Sub 20] | - | Club León [Sub 20] | 2:1 |  |
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| 16. Jornada | 24.04.2022 | Santos Laguna [Sub 20] | - | Club León [Sub 20] | 0:3 |
México