| 23. Jornada | 06.02.2022 | Lorient | - | RC Lens | 2:0 |  |
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| 24. Jornada | 13.02.2022 | Mónaco | - | Lorient | 0:0 | ||||
| 25. Jornada | 20.02.2022 | Lorient | - | Montpellier | 0:1 | ||||
| 26. Jornada | 27.02.2022 | Stade Brestois 29 | - | Lorient | 0:1 | |
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| 27. Jornada | 04.03.2022 | Lorient | - | Lyon | 1:4 | ||||
| 28. Jornada | 13.03.2022 | Clermont Foot 63 | - | Lorient | 0:2 | |
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| 29. Jornada | 20.03.2022 | Lorient | - | RC Strasbourg | 0:0 | ||||
| 30. Jornada | 03.04.2022 | París Saint-Germain | - | Lorient | 5:1 | |
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| 31. Jornada | 08.04.2022 | Lorient | - | Saint-Étienne | 6:2 | |
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| 32. Jornada | 17.04.2022 | Niza | - | Lorient | 2:1 | ||||
| 33. Jornada | 20.04.2022 | Lorient | - | FC Metz | 1:0 | ||||
| 34. Jornada | 24.04.2022 | Rennes | - | Lorient | 5:0 | ||||
| 35. Jornada | 01.05.2022 | Lorient | - | Stade de Reims | 1:2 | ||||
| 36. Jornada | 08.05.2022 | Lorient | - | Marsella | 0:3 | ||||
| 37. Jornada | 14.05.2022 | Girondins de Burdeos | - | Lorient | 0:0 | ||||
| 38. Jornada | 21.05.2022 | Lorient | - | Troyes | 1:1 |
Malí