| 2. Jornada | 21.07.2022 | Tacuary | - | Cerro Porteño | 0:1 | ||||
| 3. Jornada | 23.07.2022 | Sportivo Ameliano | - | Tacuary | 2:0 |  |
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| 6. Jornada | 16.08.2022 | Tacuary | - | Resistencia SC | 1:1 | ||||
| 7. Jornada | 21.08.2022 | 12 de Octubre de Itauguá | - | Tacuary | 0:2 | ||||
| 8. Jornada | 29.08.2022 | Tacuary | - | Sol de América | 1:0 | ||||
| 9. Jornada | 04.09.2022 | Club Nacional | - | Tacuary | 1:0 | ||||
| 10. Jornada | 11.09.2022 | Tacuary | - | Guaraní | 2:0 | ||||
| 11. Jornada | 14.09.2022 | Libertad | - | Tacuary | 2:0 | ||||
| 12. Jornada | 19.09.2022 | Guaireña FC | - | Tacuary | 1:0 | ||||
| 13. Jornada | 26.09.2022 | Cerro Porteño | - | Tacuary | 5:0 | ||||
| 20. Jornada | 31.10.2022 | Tacuary | - | Club Nacional | 2:1 | ||||
| 21. Jornada | 06.11.2022 | Guaraní | - | Tacuary | 2:1 | ||||
| 22. Jornada | 12.11.2022 | Tacuary | - | Libertad | 1:0 |
Brasil