| 3. Jornada | 05.07.2022 | Santos Laguna [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 3:1 | ||||
| 2. Jornada | 09.07.2022 | Deportivo Guadalajara [Sub 18] | - | Atlético San Luis [Sub 18] | 3:1 | ||||
| 5. Jornada | 27.07.2022 | Gallos Blancos [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 0:1 |  |
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| 6. Jornada | 30.07.2022 | Deportivo Guadalajara [Sub 18] | - | CF Pachuca [Sub 18] | 0:1 | ||||
| 7. Jornada | 05.08.2022 | Mazatlán FC [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 2:2 | ||||
| 13. Jornada | 07.09.2022 | Club Tijuana [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 1:0 | ||||
| 14. Jornada | 10.09.2022 | Deportivo Guadalajara [Sub 18] | - | Puebla FC [Sub 18] | 1:1 | ||||
| 15. Jornada | 17.09.2022 | CF América [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 0:3 | |
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| 16. Jornada | 28.09.2022 | Deportivo Guadalajara [Sub 18] | - | CF Monterrey [Sub 18] | 4:0 |
México