| 1. Jornada | 23.08.2021 | Apollon Limassol | - | Ethnikos Achna | 4:2 |  |
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| 2. Jornada | 11.09.2021 | Aris Limassol | - | Apollon Limassol | 0:1 | ||||
| 3. Jornada | 19.09.2021 | Apollon Limassol | - | APOEL Nikosia | 2:1 | ||||
| 4. Jornada | 26.09.2021 | AEL Limassol | - | Apollon Limassol | 0:1 | ||||
| 5. Jornada | 01.10.2021 | Apollon Limassol | - | AEK Larnaca | 1:4 | |
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| 6. Jornada | 17.10.2021 | Omonia Nikosia | - | Apollon Limassol | 1:0 | ||||
| 7. Jornada | 23.10.2021 | Apollon Limassol | - | Paphos FC | 2:0 | |
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| 8. Jornada | 31.10.2021 | Olympiacos Nikosia | - | Apollon Limassol | 0:2 |  |
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| 9. Jornada | 05.11.2021 | Apollon Limassol | - | Doxa Katokopias | 3:0 | ||||
| 13. Jornada | 12.12.2021 | Apollon Limassol | - | Aris Limassol | 0:2 | ||||
| 18. Jornada | 22.01.2022 | Paphos FC | - | Apollon Limassol | 0:1 | |
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| 19. Jornada | 30.01.2022 | Apollon Limassol | - | Olympiacos Nikosia | 2:1 | ||||
| 20. Jornada | 07.02.2022 | Doxa Katokopias | - | Apollon Limassol | 0:3 | ||||
| 15. Jornada | 10.02.2022 | Apollon Limassol | - | AEL Limassol | 2:1 | |
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| 21. Jornada | 15.02.2022 | PAEEK | - | Apollon Limassol | 2:2 | ||||
| 22. Jornada | 26.02.2022 | Apollon Limassol | - | Anorthosis Famagusta | 2:2 |
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