| 2. Jornada | 24.03.2021 | Gualaceo SC | - | Atlético Porteño | 3:0 | ||||
| 3. Jornada | 01.04.2021 | Chacaritas FC | - | Gualaceo SC | 2:0 | ||||
| 5. Jornada | 14.04.2021 | Independiente Juniors | - | Gualaceo SC | 2:0 | ||||
| 16. Jornada | 20.06.2021 | Gualaceo SC | - | Liga de Portoviejo | 0:0 |  |
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| 19. Jornada | 03.07.2021 | Atlético Santo Domingo | - | Gualaceo SC | 1:4 | |
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| 21. Jornada | 11.07.2021 | Gualaceo SC | - | Guayaquil SC | 2:0 | ||||
| 26. Jornada | 04.08.2021 | Liga de Portoviejo | - | Gualaceo SC | 1:1 | ||||
| 27. Jornada | 11.08.2021 | Gualaceo SC | - | El Nacional | 1:0 | |
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| 30. Jornada | 01.09.2021 | Gualaceo SC | - | Chacaritas FC | 0:1 | ||||
| 31. Jornada | 08.09.2021 | Atlético Porteño | - | Gualaceo SC | 0:1 | ||||
| 32. Jornada | 15.09.2021 | Gualaceo SC | - | Cumbayá | 3:1 | ||||
| 36. Jornada | 13.10.2021 | Gualaceo SC | - | Atlético Santo Domingo | 1:0 |
Ecuador