| 1. Jornada | 18.09.2021 | CF Pachuca [] | - | Deportivo Toluca [] | 5:0 |  |
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| 2. Jornada | 25.09.2021 | Cruz Azul [] | - | CF Pachuca [] | 3:6 | ||||
| 3. Jornada | 02.10.2021 | CF Pachuca [] | - | Puebla FC [] | 4:0 | |
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| 6. Jornada | 23.10.2021 | Club Tijuana [] | - | CF Pachuca [] | 4:2 | ||||
| 8. Jornada | 06.11.2021 | CF Pachuca [] | - | CF América [] | 5:3 | |
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| 9. Jornada | 13.11.2021 | Deportivo Toluca [] | - | CF Pachuca [] | 4:3 | ||||
| 10. Jornada | 20.11.2021 | CF Pachuca [] | - | Gallos Blancos [] | 2:1 | |
México