| 1. Jornada | 24.01.2016 | Club Nacional | - | Guaraní | 2:1 |  |
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| 4. Jornada | 08.02.2016 | Guaraní | - | Cerro Porteño | 0:0 | ||||
| 5. Jornada | 15.02.2016 | Sportivo Luqueño | - | Guaraní | 1:2 | ||||
| 6. Jornada | 21.02.2016 | Guaraní | - | General Caballero ZC | 1:2 | ||||
| 7. Jornada | 27.02.2016 | River Plate | - | Guaraní | 1:1 | ||||
| 8. Jornada | 01.03.2016 | Club Rubio Ñu | - | Guaraní | 2:2 |  |
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| 10. Jornada | 14.03.2016 | Sol de América | - | Guaraní | 0:0 | ||||
| 11. Jornada | 20.03.2016 | Guaraní | - | Libertad | 1:3 | |
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| 3. Jornada | 26.03.2016 | General Díaz | - | Guaraní | 3:2 | |
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| 12. Jornada | 03.04.2016 | Guaraní | - | Club Nacional | 1:0 | |
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| 13. Jornada | 07.04.2016 | Deportivo Capiatá | - | Guaraní | 0:2 | |
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| 15. Jornada | 18.04.2016 | Cerro Porteño | - | Guaraní | 3:4 | |
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| 16. Jornada | 22.04.2016 | Guaraní | - | Sportivo Luqueño | 3:2 | ||||
| 18. Jornada | 01.05.2016 | Guaraní | - | River Plate | 4:2 | |
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| 19. Jornada | 05.05.2016 | Guaraní | - | Club Rubio Ñu | 3:1 | ||||
| 20. Jornada | 10.05.2016 | Club Olimpia | - | Guaraní | 3:2 | ||||
| 22. Jornada | 22.05.2016 | Libertad | - | Guaraní | 0:0 | |
Paraguay