| 1. Jornada | 16.01.2022 | Alianza | - | Isidro Metapán | 0:2 |  |
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| 3. Jornada | 27.01.2022 | Alianza | - | AD Chalatenango | 3:1 | ||||
| 5. Jornada | 06.02.2022 | Alianza | - | Luis Ángel Firpo | 0:0 | ||||
| 6. Jornada | 10.02.2022 | Santa Tecla FC | - | Alianza | 2:3 |  |
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| 8. Jornada | 20.02.2022 | Municipal Limeño | - | Alianza | 0:0 | ||||
| 9. Jornada | 23.02.2022 | Once Municipal | - | Alianza | 1:2 | ||||
| 4. Jornada | 03.03.2022 | Alianza | - | FAS | 1:1 |  |
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| 11. Jornada | 06.03.2022 | Alianza | - | CD Águila | 0:0 | ||||
| 13. Jornada | 20.03.2022 | Alianza | - | Jocoro FC | 2:1 | |
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| 14. Jornada | 25.03.2022 | AD Chalatenango | - | Alianza | 2:0 | ||||
| 16. Jornada | 10.04.2022 | Luis Ángel Firpo | - | Alianza | 0:1 | ||||
| 17. Jornada | 13.04.2022 | Alianza | - | Santa Tecla FC | 2:2 | ||||
| 19. Jornada | 24.04.2022 | Alianza | - | Municipal Limeño | 4:0 | ||||
| 20. Jornada | 29.04.2022 | Alianza | - | Once Municipal | 1:0 | ||||
| 22. Jornada | 07.05.2022 | CD Águila | - | Alianza | 3:1 |
El Salvador