| 7. Jornada | 11.09.2021 | CSKA Sofia | - | Slavia Sofia | 1:1 | ||||
| 8. Jornada | 19.09.2021 | Slavia Sofia | - | PFC Ludogorets Razgrad | 1:0 | ||||
| 9. Jornada | 27.09.2021 | Lokomotiv Sofia | - | Slavia Sofia | 1:0 | ||||
| 10. Jornada | 02.10.2021 | Slavia Sofia | - | Pirin Blagoevgrad | 1:1 |  |
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| 11. Jornada | 17.10.2021 | Cherno More Varna | - | Slavia Sofia | 1:1 | ||||
| 12. Jornada | 23.10.2021 | Arda Kardzhali | - | Slavia Sofia | 1:1 | ||||
| 13. Jornada | 30.10.2021 | Slavia Sofia | - | Botev Vratsa | 1:0 |  |
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| 18. Jornada | 05.12.2021 | Slavia Sofia | - | Lokomotiv Plovdiv | 1:1 | ||||
| 19. Jornada | 11.12.2021 | CSKA 1948 Sofia | - | Slavia Sofia | 1:1 | |
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| 20. Jornada | 20.02.2022 | Slavia Sofia | - | CSKA Sofia | 2:3 | ||||
| 21. Jornada | 26.02.2022 | PFC Ludogorets Razgrad | - | Slavia Sofia | 3:1 | ||||
| 22. Jornada | 07.03.2022 | Slavia Sofia | - | Lokomotiv Sofia | 3:0 | ||||
| 23. Jornada | 14.03.2022 | Pirin Blagoevgrad | - | Slavia Sofia | 0:0 | |
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| 24. Jornada | 20.03.2022 | Slavia Sofia | - | Cherno More Varna | 0:1 | ||||
| 25. Jornada | 02.04.2022 | Slavia Sofia | - | Arda Kardzhali | 1:0 | ||||
| 26. Jornada | 08.04.2022 | Botev Vratsa | - | Slavia Sofia | 2:1 |
Bulgaria