| 1. Jornada | 24.07.2021 | CF Monterrey [Sub 16] | - | Santos Laguna [Sub 16] | 4:4 | ||||
| 3. Jornada | 07.08.2021 | Santos Laguna [Sub 16] | - | UANL Tigres [Sub 16] | 3:1 | ||||
| 4. Jornada | 14.08.2021 | Deportivo Guadalajara [Sub 16] | - | Santos Laguna [Sub 16] | 0:0 | ||||
| 6. Jornada | 28.08.2021 | Atlas Guadalajara [Sub 16] | - | Santos Laguna [Sub 16] | 1:5 | ||||
| 8. Jornada | 11.09.2021 | Santos Laguna [Sub 16] | - | Mazatlán FC [Sub 16] | 4:2 | ||||
| 9. Jornada | 18.09.2021 | Club Necaxa [Sub 16] | - | Santos Laguna [Sub 16] | 1:1 | ||||
| 10. Jornada | 25.09.2021 | Santos Laguna [Sub 16] | - | Atlas Guadalajara [Sub 16] | 1:2 |
México