2. Jornada | 16.01.2022 | UANL Tigres | - | Puebla FC | 0:2 | ||||
3. Jornada | 29.01.2022 | Puebla FC | - | Club Tijuana | 3:1 | ||||
4. Jornada | 06.02.2022 | Gallos Blancos | - | Puebla FC | 0:2 | ||||
9. Jornada | 06.03.2022 | Cruz Azul | - | Puebla FC | 1:3 | ||||
12. Jornada | 03.04.2022 | Deportivo Toluca | - | Puebla FC | 2:1 | ||||
13. Jornada | 09.04.2022 | Puebla FC | - | Pumas UNAM | 2:2 | ||||
14. Jornada | 17.04.2022 | Club León | - | Puebla FC | 0:1 | ||||
15. Jornada | 20.04.2022 | CF Pachuca | - | Puebla FC | 1:0 | ||||
17. Jornada | 30.04.2022 | Mazatlán FC | - | Puebla FC | 2:1 |