| 12. Jornada | 05.11.2021 | NK Sesvete | - | NK Opatija | 2:1 | ||||
| 13. Jornada | 20.11.2021 | NK Opatija | - | NK Dugopolje | 0:2 | ||||
| 14. Jornada | 27.11.2021 | NK Dubrava | - | NK Opatija | 1:0 | ||||
| 15. Jornada | 04.12.2021 | NK Opatija | - | HNK Orijent Rijeka | 0:1 | ||||
| 16. Jornada | 12.02.2022 | NK Opatija | - | HNK Cibalia | 2:1 | ||||
| 18. Jornada | 26.02.2022 | NK Opatija | - | NK Kustošija | 2:1 |  |
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| 19. Jornada | 06.03.2022 | NK BSK Bijelo Brdo | - | NK Opatija | 4:1 | ||||
| 20. Jornada | 12.03.2022 | NK Opatija | - | Dinamo Zagreb II | 0:0 | ||||
| 21. Jornada | 19.03.2022 | NK Solin | - | NK Opatija | 1:0 | ||||
| 22. Jornada | 02.04.2022 | NK Opatija | - | NK Croatia Zmijavci | 2:1 | |
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| 23. Jornada | 09.04.2022 | NK Opatija | - | NK Osijek II | 1:2 | ||||
| 24. Jornada | 16.04.2022 | NK Varaždin | - | NK Opatija | 4:0 |
Croacia