| 1. Jornada | 24.07.2021 | Sparta Praga | - | Sigma Olomouc | 3:2 |  |
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| 2. Jornada | 31.07.2021 | Sigma Olomouc | - | FK Pardubice | 3:2 | ||||
| 4. Jornada | 14.08.2021 | Sigma Olomouc | - | Dynamo České Budějovice | 3:3 | ||||
| 5. Jornada | 21.08.2021 | FC Fastav Zlín | - | Sigma Olomouc | 1:4 | ||||
| 6. Jornada | 29.08.2021 | Sigma Olomouc | - | FK Jablonec | 4:0 | ||||
| 7. Jornada | 12.09.2021 | FK Mladá Boleslav | - | Sigma Olomouc | 3:3 | ||||
| 8. Jornada | 17.09.2021 | Sigma Olomouc | - | Baník Ostrava | 1:1 | |
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| 9. Jornada | 26.09.2021 | FK Teplice | - | Sigma Olomouc | 0:0 | ||||
| 10. Jornada | 02.10.2021 | Bohemians Praha 1905 | - | Sigma Olomouc | 2:0 | ||||
| 11. Jornada | 17.10.2021 | Sigma Olomouc | - | MFK Karviná | 2:0 | ||||
| 3. Jornada | 27.10.2021 | Slavia Praga | - | Sigma Olomouc | 1:0 | ||||
| 14. Jornada | 06.11.2021 | Viktoria Plzeň | - | Sigma Olomouc | 0:0 | ||||
| 15. Jornada | 20.11.2021 | Sigma Olomouc | - | FC Hradec Králové | 2:2 | ||||
| 16. Jornada | 27.11.2021 | FK Pardubice | - | Sigma Olomouc | 1:5 | ||||
| 17. Jornada | 04.12.2021 | Sigma Olomouc | - | Slavia Praga | 0:1 | ||||
| 18. Jornada | 12.12.2021 | Dynamo České Budějovice | - | Sigma Olomouc | 2:1 | ||||
| 30. Jornada | 20.04.2022 | Sigma Olomouc | - | Sparta Praga | 2:0 |
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