| 1. Jornada | 08.08.2020 | MFK Zemplín Michalovce | - | Spartak Trnava | 0:2 |  |
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| 2. Jornada | 11.08.2020 | Spartak Trnava | - | MFK Ružomberok | 3:1 | |
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| 3. Jornada | 15.08.2020 | Spartak Trnava | - | FK Pohronie | 1:1 | |
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| 4. Jornada | 22.08.2020 | FC DAC 1904 | - | Spartak Trnava | 2:1 | ||||
| 5. Jornada | 29.08.2020 | Spartak Trnava | - | ŠKF Sereď | 0:2 | ||||
| 6. Jornada | 12.09.2020 | Slovan Bratislava | - | Spartak Trnava | 2:0 | ||||
| 7. Jornada | 19.09.2020 | Spartak Trnava | - | Zlaté Moravce | 1:0 | ||||
| 9. Jornada | 03.10.2020 | Spartak Trnava | - | FC Nitra | 0:2 | ||||
| 10. Jornada | 18.10.2020 | MŠK Žilina | - | Spartak Trnava | 2:1 | ||||
| 11. Jornada | 24.10.2020 | Spartak Trnava | - | AS Trenčín | 2:0 | ||||
| 12. Jornada | 31.10.2020 | Spartak Trnava | - | MFK Zemplín Michalovce | 1:2 | |
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| 13. Jornada | 07.11.2020 | MFK Ružomberok | - | Spartak Trnava | 0:1 | ||||
| 14. Jornada | 21.11.2020 | FK Pohronie | - | Spartak Trnava | 3:3 | |
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| 15. Jornada | 28.11.2020 | Spartak Trnava | - | FC DAC 1904 | 0:2 | |
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| 17. Jornada | 13.12.2020 | Spartak Trnava | - | Slovan Bratislava | 0:3 | ||||
| 18. Jornada | 06.02.2021 | Zlaté Moravce | - | Spartak Trnava | 2:4 | ||||
| 19. Jornada | 13.02.2021 | Spartak Trnava | - | FK Senica | 1:0 |
Eslovaquia