| 1. Jornada | 01.08.2021 | Xelaju MC | - | Cobán Imperial | 3:0 |  |
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| 3. Jornada | 18.08.2021 | Nueva Concepción | - | Cobán Imperial | 2:1 | ||||
| 5. Jornada | 22.08.2021 | Comunicaciones | - | Cobán Imperial | 2:2 | ||||
| 6. Jornada | 25.08.2021 | Deportivo Malacateco | - | Cobán Imperial | 1:0 | ||||
| 7. Jornada | 29.08.2021 | Cobán Imperial | - | Antigua GFC | 0:2 | ||||
| 9. Jornada | 11.09.2021 | Cobán Imperial | - | Santa Lucía | 0:1 | ||||
| 10. Jornada | 18.09.2021 | CSD Municipal | - | Cobán Imperial | 2:1 | ||||
| 14. Jornada | 17.10.2021 | Cobán Imperial | - | Nueva Concepción | 2:0 | ||||
| 15. Jornada | 23.10.2021 | Achuapa | - | Cobán Imperial | 1:0 | ||||
| 16. Jornada | 27.10.2021 | Cobán Imperial | - | Comunicaciones | 1:2 | ||||
| 21. Jornada | 28.11.2021 | Cobán Imperial | - | CSD Municipal | 0:1 | ||||
| 22. Jornada | 05.12.2021 | Iztapa | - | Cobán Imperial | 5:3 |  |
Brasil