| 1. Jornada | 19.07.2022 | AD Guanacasteca | - | CS Herediano | 0:2 | ||||
| 4. Jornada | 08.08.2022 | Santos de Guápiles | - | AD Guanacasteca | 0:1 |  |
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| 5. Jornada | 11.08.2022 | AD Guanacasteca | - | Guadalupe | 1:2 | ||||
| 6. Jornada | 15.08.2022 | Guadalupe | - | AD Guanacasteca | 1:0 | ||||
| 7. Jornada | 21.08.2022 | AD Guanacasteca | - | LD Alajuelense | 1:2 | ||||
| 8. Jornada | 28.08.2022 | Sporting FC | - | AD Guanacasteca | 4:1 | ||||
| 9. Jornada | 31.08.2022 | CS Herediano | - | AD Guanacasteca | 3:0 | ||||
| 10. Jornada | 04.09.2022 | AD Guanacasteca | - | Santos de Guápiles | 1:0 | ||||
| 12. Jornada | 17.09.2022 | AD Guanacasteca | - | Municipal Pérez Zeledón | 0:2 | ||||
| 15. Jornada | 29.09.2022 | Deportivo Saprissa | - | AD Guanacasteca | 1:0 | ||||
| 16. Jornada | 02.10.2022 | AD Guanacasteca | - | CS Cartaginés | 1:1 | |
Nicaragua