| 2. Jornada | 02.05.2021 | San Antonio FC | - | Colorado Springs Switchbacks | 3:0 | ||||
| 2. Jornada | 09.05.2021 | San Antonio FC | - | Real Monarchs SLC | 2:2 | ||||
| 2. Jornada | 17.05.2021 | Rio Grande Valley FC | - | San Antonio FC | 2:1 |  |
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| 2. Jornada | 30.05.2021 | San Antonio FC | - | Rio Grande Valley FC | 1:1 | ||||
| 4. Jornada | 17.07.2021 | Colorado Springs Switchbacks | - | San Antonio FC | 2:3 | ||||
| 4. Jornada | 22.07.2021 | San Antonio FC | - | New Mexico United | 3:0 | ||||
| 5. Jornada | 05.08.2021 | El Paso Locomotive | - | San Antonio FC | 2:0 | ||||
| 5. Jornada | 09.08.2021 | Rio Grande Valley FC | - | San Antonio FC | 1:2 | |
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| 5. Jornada | 29.08.2021 | San Antonio FC | - | El Paso Locomotive | 2:1 | ||||
| 6. Jornada | 02.09.2021 | San Antonio FC | - | Real Monarchs SLC | 3:2 | ||||
| 7. Jornada | 04.10.2021 | OKC Energy FC | - | San Antonio FC | 0:1 | ||||
| 7. Jornada | 07.10.2021 | El Paso Locomotive | - | San Antonio FC | 3:3 | ||||
| 7. Jornada | 11.10.2021 | San Antonio FC | - | Memphis 901 | 4:2 |  |
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| 7. Jornada | 17.10.2021 | San Antonio FC | - | FC Tulsa | 1:1 | ||||
| 7. Jornada | 24.10.2021 | San Antonio FC | - | Austin Bold | 0:0 | |
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| 7. Jornada | 31.10.2021 | San Antonio FC | - | Colorado Springs Switchbacks | 3:0 | |
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