| 1. Jornada | 19.01.2025 | Juticalpa | - | Marathón | 0:0 | ||||
| 2. Jornada | 25.01.2025 | Marathón | - | Victoria | 0:1 | ||||
| 3. Jornada | 31.01.2025 | Motagua | - | Marathón | 2:2 |  |
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| 4. Jornada | 02.02.2025 | Marathón | - | Real Sociedad | 1:1 | ||||
| 5. Jornada | 08.02.2025 | Real España | - | Marathón | 1:2 | ||||
| 6. Jornada | 14.02.2025 | Marathón | - | Olancho FC | 2:0 | ||||
| 7. Jornada | 18.02.2025 | Deportivo Génesis | - | Marathón | 1:1 | |
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| 8. Jornada | 24.02.2025 | Olimpia | - | Marathón | 1:0 | |
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| 9. Jornada | 01.03.2025 | Marathón | - | Lobos UPNFM | 3:3 |  |
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| 11. Jornada | 14.03.2025 | Victoria | - | Marathón | 1:4 | ||||
| 12. Jornada | 30.03.2025 | Marathón | - | Motagua | 1:1 | ||||
| 13. Jornada | 03.04.2025 | Real Sociedad | - | Marathón | 0:2 | ||||
| 14. Jornada | 07.04.2025 | Marathón | - | Real España | 1:0 | ||||
| 15. Jornada | 13.04.2025 | Olancho FC | - | Marathón | 0:1 | ||||
| 16. Jornada | 19.04.2025 | Marathón | - | Deportivo Génesis | 0:0 | ||||
| 17. Jornada | 28.04.2025 | Marathón | - | Olimpia | 1:2 |  |
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Panamá