| 6. Jornada | 19.02.2022 | Puebla FC | - | CF Monterrey | 1:0 |  |
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| 7. Jornada | 27.02.2022 | Deportivo Guadalajara | - | Puebla FC | 2:3 | ||||
| 8. Jornada | 02.03.2022 | Puebla FC | - | FC Juárez | 1:1 | |
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| 9. Jornada | 06.03.2022 | Cruz Azul | - | Puebla FC | 1:3 | ||||
| 10. Jornada | 14.03.2022 | Atlético San Luis | - | Puebla FC | 2:1 | ||||
| 11. Jornada | 19.03.2022 | Puebla FC | - | Santos Laguna | 2:2 | |
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| 12. Jornada | 03.04.2022 | Deportivo Toluca | - | Puebla FC | 2:1 | ||||
| 13. Jornada | 09.04.2022 | Puebla FC | - | Pumas UNAM | 2:2 | ||||
| 14. Jornada | 17.04.2022 | Club León | - | Puebla FC | 0:1 | |
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| 15. Jornada | 20.04.2022 | CF Pachuca | - | Puebla FC | 1:0 | |
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| 17. Jornada | 30.04.2022 | Mazatlán FC | - | Puebla FC | 2:1 | |
México