| 2. Jornada | 30.01.2022 | Leones FC | - | Boca Juniors de Cali | 2:1 |  |
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| 3. Jornada | 06.02.2022 | Valledupar FC | - | Leones FC | 0:1 | ||||
| 4. Jornada | 13.02.2022 | Leones FC | - | Tigres FC | 3:1 | |
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| 1. Jornada | 17.02.2022 | Boyacá Chicó | - | Leones FC | 1:0 | ||||
| 5. Jornada | 19.02.2022 | Fortaleza FC | - | Leones FC | 1:2 | |
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| 6. Jornada | 27.02.2022 | Leones FC | - | Barranquilla FC | 3:1 | |
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| 7. Jornada | 07.03.2022 | Atlético Huila | - | Leones FC | 1:1 | |
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| 8. Jornada | 10.03.2022 | Leones FC | - | Real Cartagena | 1:0 | ||||
| 9. Jornada | 21.03.2022 | Real Santander | - | Leones FC | 0:4 | |
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| 10. Jornada | 26.03.2022 | Leones FC | - | Atlético FC | 1:1 | |
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| 12. Jornada | 09.04.2022 | Bogotá FC | - | Leones FC | 1:0 | ||||
| 13. Jornada | 18.04.2022 | Leones FC | - | Orsomarso SC | 3:1 | ||||
| 14. Jornada | 23.04.2022 | Llaneros FC | - | Leones FC | 1:0 | |
Colombia